https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815616/
Early-Onset Alzheimer's Disease: What Is Missing in Research? - PMC
Jan 19, 2021 ... EOAD cases make up 5–10% of AD cases but only 10–15% of these cases show known mutations in the APP, PSEN1, and PSEN2, which are linked to EOAD.